Lipids & metabolic liver disease
Characterization of brain morphology associated with metabolic dysfunction‐associated steatotic liver disease in the UK Biobank
Authors' conclusion
Brain morphology associated with MASLD is characterized by smaller subcortical grey matter volume and higher coherence but lower magnitudes of white matter microstructure.
Study context
- Population
- Individuals aged 45–82 years in the UK Biobank who undertook an magnetic resonance imaging (MRI) sub-study between 2014 and 2022
- Participants
- 29,195 individuals
- Exposure
- MASLD vs no MASLD
- Outcome
- Volumes of total brain tissue and subcortical grey matter, and white matter microstructures
Main finding
As reported in the abstract
Brain morphology
Multivariable-adjusted β
- Reduced Alzheimer's disease (AD)-signature cortical thickness
- −0.04 (95% CI −0.07 to −0.01)
- Higher total white matter hyperintensity volume
- 0.12 (95% CI 0.10–0.15)
- Increased global fractional anisotropy (FA)
- 0.05 (95% CI 0.03–0.08)
- Reduced global MD
- −0.04 (95% CI −0.07 to −0.01)
- MASLD associated with smaller volumes of total grey matter and subcortical grey matter
- P < 0.05
Observational data: associations, not effects.
Original publication
Characterization of brain morphology associated with metabolic dysfunction‐associated steatotic liver disease in the UK Biobank. Diabetes Obes Metab. Published 2 April 2025. doi:10.
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