Lipids & metabolic liver disease
Non-Esterified Fatty Acid Profiles and Cause-Specific Mortality: The Cardiovascular Health Study
Authors' conclusion
Individual fasting NEFAs represent attractive candidates for medical and public health interventions aimed at improving survivorship in older adults and should be investigated further.
Study context
- Population
- Community-dwelling adults >64 years from 4 US communities (Cardiovascular Health Study); mean age 78 years, 60.5% female1,678 died
- Participants
- 1,996 adults
- Exposure
- Fasting and post-load total non-esterified fatty acid (NEFA), NEFA subclasses and individual NEFA vs mortality
- Outcome
- All-cause mortality
- Follow-up
- median 11-year follow-up
Methodological details4 US communities
- 4 US communities
Main finding
As reported in the abstract
Total fasting NEFA (aHR per SD), 95% CI 1.10-1.23
1.17
Observational data: associations, not effects.
Further findings
Total mortality by NEFA subclass
- Only monounsaturated fatty acid (MUFA) associated with total mortality (aHR), 95% CI 1.09-1.41
- 1.24
All-cause mortality by individual NEFA
- Nervonic acid (aHR), 95% CI 1.01-1.12
- 1.06
- Petroselaidic acid (aHR), 95% CI 1.03-1.42
- 1.21
- Eicosapentaenoic acid (aHR), 95% CI 0.82-0.99
- 0.90
Original publication
Non-Esterified Fatty Acid Profiles and Cause-Specific Mortality: The Cardiovascular Health Study. J Clin Endocrinol Metab. Published 24 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →