Lipids & metabolic liver disease
Sex differences in the relationship between serum total bilirubin and risk of incident metabolic syndrome in community-dwelling adults: Propensity score analysis using longitudinal cohort data over 16 years
Authors' conclusion
Serum total bilirubin levels were significantly inversely associated with MetS in women, but there was no significant association observed in men. Sex differences in the effects of serum total bilirubin should be noted when predicting incident MetS by sex in clinical settings.
Study context
- Population
- Community-dwelling adults aged 40–69 years without metabolic syndrome (MetS), Korean Genome Epidemiology Study; 3,089 men and 2,096 women3,089 men · 2,096 women
- Participants
- 5,185 adults
- Exposure
- Highest vs lowest sex-specific quartile of serum total bilirubin
- Outcome
- Incident metabolic syndrome
- Follow-up
- Biennial for 16 years (until 2018)
Methodological detailspropensity score matched, sex-stratified, 16-year follow-up
- Propensity score matched
- Sex-stratified
- 16-year follow-up
Main finding
As reported in the abstract
Incident MetS, highest vs lowest serum total bilirubin quartile, by sex
Highest quartile vs Lowest quartileHazard ratio (95% CI)
Men
1.00(0.80–1.24)
Women
0.80(0.65–0.99)
Observational data: associations, not effects.
Further findings
Incidence rate per 1000 person-years across bilirubin quartiles
- Incidence rate decreased proportionally with increasing quartiles in both men and women
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sex differences in the relationship between serum total bilirubin and risk of incident metabolic syndrome in community-dwelling adults: Propensity score analysis using longitudinal cohort data over 16 years. Cardiovasc Diabetol. Published 11 March 2024. doi:10.
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