Lipids & metabolic liver disease
Triglyceride–Glucose Index and Risks of All-Cause and Cause-Specific Mortality in Young Adults
Errata to this article were published (J Clin Endocrinol Metab, 18 Nov 2025 ↗ · 20 Feb 2026 ↗)
Authors' conclusion
The TyG index can be a useful marker to identify young individuals at an increased risk of all-cause, cardiovascular, and respiratory mortality.
Study context
- Population
- Individuals aged 20–39 years who underwent Korean national health screening, 2009–2012
- Participants
- 6,667,138 individuals
- Exposure
- Triglyceride-glucose (TyG) index quartiles
- Outcome
- All-cause mortality and cause-specific (CVD, cancer, respiratory) mortality
- Follow-up
- Median 10.7 years
Methodological detailsnationwide health screening cohort, multivariable Cox analysis
- Nationwide health screening cohort
- Multivariable Cox analysis
Main finding
As reported in the abstract
All-cause, CVD, respiratory and cancer mortality
Q4 vs Q1Adjusted hazard ratio (95% CI)
All-cause mortality
1.21(1.17–1.24)
CVD mortality
1.42(1.29–1.56)
Respiratory mortality
1.68(1.21–2.34)
- Deaths during follow-up
- 41 004 (0.6%)
Observational data: associations, not effects.
Original publication
Triglyceride–Glucose Index and Risks of All-Cause and Cause-Specific Mortality in Young Adults. J Clin Endocrinol Metab. Published 19 March 2025. doi:10.
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