Lipids & metabolic liver disease
Acute kidney injury is associated with liver-related events in patients with metabolic dysfunction-associated fatty liver disease
Main finding · Composite liver outcomeResult — go to the resultAdjusted hazard ratio 1.83 95% CI 1.38–2.41Authors' conclusion
AKI was significantly associated with an increased risk of liver-related events among patients with MAFLD. These findings suggest that enhanced vigilance toward AKI may be justifiable in MAFLD patients.
Study context
- Population
- Chinese adults with MAFLD, China Renal Data System (CRDS) database; median age 59.17 years, 54.7% male
- Participants
- 50,499 adults
- Exposure
- Acute kidney injury (AKI) vs no AKI during hospitalization
- AKIn = 3,711
- Outcome
- Composite of:
- Liver-related mortality
- Major adverse liver outcomes
Main finding
Composite liver outcome
Adjusted hazard ratio
1.83
95% CI 1.38–2.41
P < 0.001
AKIvs No AKI
aHR 1.83 (95% CI 1.38–2.41); P < 0.001
As reported in the abstract
- Patients with composite liver outcome (overall)
- 1,660 (3.3%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (CI) | P value | |
|---|---|---|---|
| Composite liver outcome, severe AKI (stage 2/3)Severe AKI (stage 2/3)vs No AKI | 2.36 (1.57–3.54) | P < 0.001 | |
| Escalation of FIB-4 risk scores | 1.28 (1.14–1.44) | P < 0.001 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Subgroups and sensitivity analyses
- Associations remained consistent across various subgroups and sensitivity analyses
Original publication
Acute kidney injury is associated with liver-related events in patients with metabolic dysfunction-associated fatty liver disease. Diabetes Metab. Published 16 March 2025. doi:10.
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