Lipids & metabolic liver disease
Associations of intra‐pancreatic fat deposition with triglyceride‐rich lipoproteins and lipoprotein lipase
Authors' conclusion
The relationship of IPFD with triglyceride-rich lipoproteins differs depending on the nature of the lipoproteins. High IPFD is significantly associated with increased levels of IDL (specifically, its most representative subfraction-IDL-B), but not VLDL. Fatty pancreas disease may contribute to increasing the risk of atherosclerotic CVD through IDL.
Study context
- Population
- Participants who underwent 3.0 Tesla MRI for quantification of intra-pancreatic fat deposition (IPFD), with fasting blood samples
- Participants
- 174 participants
- Outcome
- Associations of IPFD with VLDL, intermediate-density lipoprotein (IDL) and lipoprotein lipase
Methodological detailsTriglyceride-rich lipoproteins measured by Lipoprint® system (very-low-density lipoprotein (VLDL), IDL-C, IDL-B, IDL-A); lipoprotein lipase by ELISA; univariable and multivariable linear regression
- Triglyceride-rich lipoproteins measured by Lipoprint® system (VLDL, IDL-C, IDL-B, IDL-A); lipoprotein lipase by ELISA; univariable and multivariable linear regression
Main finding
As reported in the abstract
IDL-B (most adjusted multivariable linear regression model)
IDL-B increase per unit increase in IPFD (p = 0.047)
0.12-unit
IDL-B increase per unit increase in lipoprotein lipase (p = 0.015)
0.22-unit
Observational data: associations, not effects.
Original publication
Associations of intra‐pancreatic fat deposition with triglyceride‐rich lipoproteins and lipoprotein lipase. Diabetes Obes Metab. Published 14 March 2025. doi:10.
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