Lipids & metabolic liver disease
The moderating effect of cardiometabolic factors on the association between hepatic and intrapancreatic fat
Authors' conclusion
The association between hepatic fat and IPFD is generally present in young and middle-aged adults with good cardiometabolic health, whereas the link between the two fat depots becomes uncoupled in older adults or individuals with cardiometabolic risk factors.
Study context
- Population
- Participants undergoing 3T abdominal magnetic resonance imaging (MRI) and spectroscopy, hepatic fat and intrapancreatic fat deposition (IPFD) manually quantified by independent raters
- Participants
- 367 participants
- Outcome
- Conditions (moderators) under which hepatic fat is associated with intrapancreatic fat deposition (IPFD)
Methodological detailsmoderation analyses, adjusted for sex and ethnicity
- Moderation analyses
- Adjusted for sex and ethnicity
Main finding
As reported in the abstract
- Significant moderators: age, HbA1c, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and TG
- p < 0.05
- Range of significance: age
- < 61 years
- Range of significance: HbA1c
- < 45 mmol/mol
- Range of significance: LDL-C
- < 157 mg/dL
- Range of significance: HDL-C
- > 36 mg/dL
- Range of significance: TG
- < 203 mg/dL
Observational data: associations, not effects.
Original publication
The moderating effect of cardiometabolic factors on the association between hepatic and intrapancreatic fat. Obesity (Silver Spring). Published 10 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →