Lipids & metabolic liver disease
Relationship of intra‐pancreatic fat deposition with low‐density lipoprotein subfractions and hepatic lipase
Authors' conclusion
The lack of a significant association between IPFD and LDL subfractions suggests that the link between IPFD and cardiovascular disease is likely mediated through mechanisms other than alterations in LDL particle distribution.
Study context
- Population
- Individuals with intra-pancreatic fat deposition (IPFD) quantified by 3.0 Tesla MRI; Low-density lipoprotein (LDL) subfractions by non-denaturing polyacrylamide gel electrophoresis
- Participants
- 174 individuals
- Outcome
- Associations of IPFD with LDL subfractions (large LDL: LDL-1, LDL-2; small LDL: LDL-3 to LDL-6) and hepatic lipase
Methodological detailsunivariate and multivariate linear regression, adjusted for age, sex, ethnicity, obesity, insulin resistance and TG
- Univariate and multivariate linear regression
- Adjusted for age, sex, ethnicity, obesity, insulin resistance and TG
Main finding
As reported in the abstract
Per unit increase in hepatic lipase, change in LDL-1 (most adjusted model)
0.24-unit decrease
p = 0.002
Per unit increase in hepatic lipase, change in LDL-2 (most adjusted model)
0.22-unit decrease
p = 0.003
Per unit increase in hepatic lipase, change in LDL-large subclass (most adjusted model)
0.27-unit decrease
p < 0.001
Observational data: associations, not effects.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →