Lipids & metabolic liver disease
Remnant cholesterol, but not low‐density lipoprotein cholesterol, is associated with intra‐pancreatic fat deposition
Authors' conclusion
Components of the lipid panel have different associations with IPFD. This may open up new opportunities for improving outcomes in people at high risk for cardiovascular diseases (who have normal low-density lipoprotein cholesterol) by reducing IPFD.
Study context
- Population
- Participants undergoing abdominal MRI on the same 3.0-Tesla scanner with fasting lipid panel
- Participants
- 348 participants
- Outcome
- Associations of lipid panel components (and derivatives) with intra-pancreatic fat deposition (IPFD)
Methodological detailslinear regression adjusted for age, sex, ethnicity, BMI, FPG, HOMA-IR and liver fat deposition
- Linear regression adjusted for age, sex, ethnicity, BMI, FPG, HOMA-IR and liver fat deposition
Main finding
As reported in the abstract
Association with total IPFD (most adjusted model)
- Remnant cholesterol positively associated with total intra-pancreatic fat deposition (IPFD)
- P = 0.010
- TG positively associated with total IPFD
- P = 0.008
- HDL-C negatively associated with total IPFD
- P = 0.001
- Remnant cholesterol explained the greatest proportion of variance in total IPFD
- 9.9%
Observational data: associations, not effects.
Original publication
Remnant cholesterol, but not low‐density lipoprotein cholesterol, is associated with intra‐pancreatic fat deposition. Diabetes Obes Metab. Published 2 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →