Lipids & metabolic liver disease
Remnant–to–LDL cholesterol discordance as a predictor of thromboembolic events in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia atrial fibrillation (AF) project III (MAFP-III) cohort study
Main finding · Thromboembolic events, low LDL-C groupResult — go to the resultAdjusted hazard ratio 1.82 95% CI 1.03–3.23Authors' conclusion
Despite low LDL-C levels in AF patients, elevated RC levels were still independently associated with a higher thromboembolic risk, suggesting discordance between RC and LDL-C in risk stratification among patients with AF.
Study context
- Population
- AF outpatients initiating oral anticoagulation, January 2016–November 2021; 52.5% female, median age 76 years (IQR 69–82); stratified into 4 groups by baseline low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC)
- Participants
- 1,694 outpatients
- Exposure
- High vs low RC levels across LDL-C strata
- Outcome
- Composite of thromboembolic events
- Follow-up
- Mean 1.86 years, SD 0.4 years
Methodological detailsMAFP-III cohort
- MAFP-III cohort
Main finding
Thromboembolic events, low LDL-C group
Adjusted hazard ratio
1.82
95% CI 1.03–3.23
P = 0.039
High RCvs Low RC
aHR 1.82 (95% CI 1.03–3.23); P = 0.039
As reported in the abstract
- Thromboembolic events, overall cohort
- 5.7% (97)
- Low LDL-C group: significant linear association between RC levels and thromboembolic risk on restricted cubic spline (RCS) analysis
- p-overall = 0.044
Observational data: associations, not effects.
Secondary outcomes
Major adverse cardiovascular events (MACE), CV death and all-cause death
- Higher RC levels not significantly associated with increased adverse event risk in either LDL-C group
Original publication
Remnant–to–LDL cholesterol discordance as a predictor of thromboembolic events in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia AF project III (MAFP-III) cohort study. Cardiovasc Diabetol. Published 10 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →