Lipids & metabolic liver disease
Modelling the direct and indirect associations between anthropometric and behavioural factors when predicting atherogenic risk index (TC/HDL-C) ratio
Authors' conclusion
These results confirm that taller, non-smokers who have smaller WC are more likely to have a lower atherogenic risk index (TC/HDL) ratio and hence be at reduced risk of IHD. Participation in regular moderate activity to reduce their WC is not necessarily or directly associated with lower atherogenic risk index (TC/HDL) and hence a lower risk of IHD. Being taller with smaller WC, possibly but not necessarily due to taking MVPA, was associated with a lower atherogenic risk index (TC/HDL-C) ratio and hence have lower risk of IHD.
Study context
- Outcome
- Association between body size and atherogenic risk index (TC/HDL ratio) associated with ischemic heart disease
Methodological detailsallometric models, mediation analysis
- Allometric models
- Mediation analysis
Main finding
As reported in the abstract
- Waist circumference (WC) and smoking had the strongest association (strongest effect sizes) with cholesterol-related indices and hence ischemic heart disease (IHD)
- Strong negative exponent or effect associated with height: taller individuals inherently have lower cholesterol-related indices
Observational data: associations, not effects.
Further findings
Mediation analysis: MPA and vigorous physical activity (VPA)
- MPA and VPA were both strongly associated with reducing WC but only VPA was directly associated with the TC/HDL
Original publication
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