Lipids & metabolic liver disease
The prognostic value of atherogenic index of plasma and thin-cap fibroatheroma among patients with ST-elevated myocardial infarction (STEMI): an optical coherence tomography prospective cohort study of real world
Authors' conclusion
Microstructural features observed via OCT for culprit lesions, combined with the AIP index-an important marker for cardiovascular disease-may be utilized clinically to support risk stratification and predict adverse events among STEMI patients.
Study context
- Population
- Patients aged ≥18 years with STEMI who underwent primary PCI and pre-intervention optical coherence tomography (OCT) imaging of culprit lesions, March 2017–March 2019; Atherogenic Index of Plasma (AIP) = log10(TG/HDL-C)
- Participants
- 274 patients
- Exposure
- AIP and Thin-Cap Fibroatheroma (TCFA) categories
- Outcome
- Incidence of MACE
Methodological detailsoptical coherence tomography, real world
- Optical coherence tomography
- Real world
Main finding
As reported in the abstract
MACE
- Kaplan-Meier risk stratification for MACE by AIP-TCFA interaction
- log-rank p = 0.027
- AIP-plaque interaction
- log-rank p = 0.033
- AIP-mixed plaque interaction
- log-rank p = 0.041
- AIP-lipid plaque interaction
- log-rank p < 0.001
- AIP-macrophage interaction
- log-rank p = 0.032
Observational data: associations, not effects.
Further findings
Baseline characteristics in Group IV
- Higher prevalence of diabetes mellitus (DM)
- P = 0.012
- Elevated TyG index
- P < 0.001
- Increased LDL-C
- P = 0.002
- Higher TG
- P < 0.001
- Elevated total cholesterol
- P = 0.001
Healing plaques by AIP tertile
- Greater frequency of healing plaques in higher AIP tertiles
- P = 0.021
- In DM, AIP correlated with plaque healing
- P < 0.05
Original publication
The prognostic value of atherogenic index of plasma and thin-cap fibroatheroma among patients with STEMI: an optical coherence tomography prospective cohort study of real world. Cardiovasc Diabetol. Published 22 October 2025. doi:10.
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