Lipids & metabolic liver disease
The predictive value of cumulative atherogenic index of plasma (AIP) for cardiovascular outcomes: a prospective community-based cohort study
Main finding · MACEResult — go to the resultHazard ratio 1.76 95% CI 1.27–2.44Authors' conclusion
A higher cumulative AIP was significantly associated with an increased risk of MACE, stroke and MI independent of traditional cardiovascular risk factors in a community-based population, and the association of cumulative AIP and stroke was particularly pronounced in the elderly population.
Study context
- Population
- Community-based adults (36.1% male, mean age 59.1 years), enrolled December 2011 to April 2012, follow-up May to July 2014; AIP = log-transformed triglyceride (TG)/HDL-C ratio
- Participants
- 3,820 adults
- Exposure
- Highest vs lowest quartile of cumulative AIP; per unit cumulative AIP
- Outcome
- MACE, stroke, MI and cardiovascular mortality
- Follow-up
- Median 7.5 years
Methodological detailsmultivariable Cox regression
- Multivariable Cox regression
Main finding
MACE
Hazard ratio
1.76
95% CI 1.27–2.44
P < 0.001
As reported in the abstract
- Major adverse cardiac events (MACE) events, total cohort
- 371 (9.7%)
- Increment in MACE incidence per one higher unit of cumulative AIP, fully adjusted model
- 75%
Observational data: associations, not effects.
Further findings
Stroke · median follow-up 7.5 years
| HR (95% CI) | P value | ||
|---|---|---|---|
| Highest cumulative AIP quartile | 1.69 (1.17–2.45) | P = 0.005 | |
| 0.512Hazard ratio (log scale) |
Myocardial infarction (MI) · median follow-up 7.5 years
| HR (95% CI) | P value | ||
|---|---|---|---|
| Highest cumulative AIP quartile | 2.82 (1.18–6.72) | P = 0.019 | |
| 0.10.31310Hazard ratio (log scale) |
| Outcome | P value |
|---|---|
| Stroke, subgroups by ageAge <65 years vs Age ≥65 years | P for interaction = 0.018 |
- Stroke — Stroke events, total cohort
- 293 (7.7%)
- MI — MI events, total cohort
- 68 (1.8%)
- Stroke, subgroups by age: HR 0.89 (<65 years) vs 2.41 (≥65 years); association more pronounced in the elderly
Cardiovascular mortality · median follow-up 7.5 years
- Cardiovascular deaths, total cohort
- 65 (1.7%)
- No significant association between cumulative AIP and cardiovascular mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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