Lipids & metabolic liver disease
Associations of insulin resistance-related indices with the risk and progression of cardiometabolic multimorbidity in individuals with metabolic dysfunction-associated steatotic liver disease: a prospective cohort study
Authors' conclusion
Among individuals with MASLD, IR-related indices were significantly associated with the incidence and progression of CMM. Indices incorporating central adiposity, especially TyG-WHtR, provided the most informative risk estimates and modest incremental predictive value.
Study context
- Population
- UK Biobank participants with MASLD free of cardiometabolic diseases (CMD) at baseline; nine insulin resistance (IR)-related indices (triglyceride-glucose (TyG), TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), TyG-body roundness index (TyG-BRI), TyG-a body shape index (TyG-ABSI), TyG-visceral adiposity index (TyG-VAI), TyG-WWI, TG/HDL-C)
- Participants
- 109,604 participants
- Exposure
- Highest vs lowest quartile of IR-related indices
- Outcome
- Incident cardiometabolic multimorbidity (CMM)
- Follow-up
- Median 15.9 years
Methodological detailsUK Biobank, multi-state models
- UK Biobank
- Multi-state models
Main finding
As reported in the abstract
- Participants developing cardiometabolic multimorbidity (CMM)
- 4944
Observational data: associations, not effects.
Further findings
Stage-specific transitions (multi-state models)
- CMD-free to single CMD: strongest associations for T2D
- Transitions from CHD or stroke more likely to progress to CMM with higher IR-related indices
Incremental CMM prediction beyond conventional risk factors
- All indices modestly improved prediction; TyG-WHtR best
- all P < 0.001
Exploratory mediation by inflammatory, hepatic and renal biomarkers
- Proportion of associations jointly accounted for
- 11-23%
- Exploratory
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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