Lipids & metabolic liver disease
Prognostic effect of triglyceride glucose-related parameters on all-cause and cardiovascular mortality in the United States adults with metabolic dysfunction-associated steatotic liver disease
Authors' conclusion
Findings of this study highlight the predictive value of TyG-related indices, especially the TyG-WHtR index, in the mortality outcomes of adults with MASLD. TyG-related indices would be surrogate biomarkers for the clinical management of MASLD.
Study context
- Population
- US adults with MASLD in National Health and Nutrition Examination Survey (NHANES) 1999–2018; median age 49.00 years4,209 men · 3,999 women
- Participants
- 8,208 adults
- Exposure
- Highest vs lowest quartile of triglyceride-glucose (TyG)-related indices
- Outcome
- All-cause and cardiovascular mortality
Methodological detailsNHANES 1999–2018
- NHANES 1999–2018
Main finding
As reported in the abstract
- TyG, all-cause mortality: aHR 1.25 (95% CI 1.05-1.50)
- P = 0.014
- TyG-waist circumference (TyG-WC), all-cause mortality: aHR 1.28 (95% CI 1.07-1.52)
- P = 0.006
- TyG-waist to height ratio (TyG-WHtR), all-cause mortality: aHR 1.50 (95% CI 1.25-1.80)
- P < 0.001
- TyG-WC, CV mortality: aHR 1.81 (95% CI 1.28-2.55)
- P = 0.001
- TyG-WHtR, CV mortality: aHR 2.22 (95% CI 1.55-3.17)
- P < 0.001
Observational data: associations, not effects.
Further findings
Concordance index (C-index) for predicting all-cause mortality
- TyG
- 0.563
- TyG-WC
- 0.579
- TyG-WHtR
- 0.585
C-index for predicting CV mortality
- TyG
- 0.561
- TyG-WC
- 0.607
- TyG-WHtR
- 0.615
Nonlinearity (restricted cubic splines (RCS))
- Nonlinear trend, TyG with all-cause mortality
- P < 0.001
- Nonlinear trend, TyG-WC with all-cause mortality
- P = 0.012
- Non-linear relationship, TyG with CV mortality
- P = 0.025
Subgroups
- Adults aged < 65 years and those without comorbidities were more sensitive to mortality prediction of TyG-related indices
Original publication
Prognostic effect of triglyceride glucose-related parameters on all-cause and cardiovascular mortality in the United States adults with metabolic dysfunction-associated steatotic liver disease. Cardiovasc Diabetol. Published 1 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →