Lipids & metabolic liver disease
Associations between cardiometabolic indices and the onset of metabolic dysfunction-associated steatotic liver disease as well as its progression to liver fibrosis: a cohort study
Authors' conclusion
The risk of developing MASLD increases as the level of cardiometabolic indices increases. Obesity may serve as a mediating factor in the aforementioned association. TyG-BMI showed the strongest association with the onset of MASLD and its progression to liver fibrosis, proved to be outperformed other cardiometabolic indicators, and could be the best clinical non-invasive biomarker for early screening of MASLD and liver fibrosis.
Study context
- Population
- Adults aged ≥18 years free of MASLD at baseline, Dalian Health Management Cohort (DHMC)
- Participants
- 25,366 adults82,445 person-years
- Exposure
- Highest vs lowest quartile of cardiometabolic indices
- Outcome
- Incident MASLD
Methodological detailsCox proportional hazards regression, restricted cubic splines, mediation analysis, time-dependent ROC
- Cox proportional hazards regression
- Restricted cubic splines
- Mediation analysis
- Time-dependent ROC
Main finding
As reported in the abstract
- Developed MASLD during follow-up
- 5378 (21.2%)
Observational data: associations, not effects.
Further findings
Progression to liver fibrosis
| HR (95% CI) | ||
|---|---|---|
| TyG-BMI | 1.36 (1.18–1.57) | |
| 0.512Hazard ratio (log scale) |
- Other cardiometabolic indices not associated with liver fibrosis
Proportion of association with MASLD mediated by BMI
- Cardiometabolic index (CMI)
- 40.4%
- Atherogenic index of plasma (AIP)
- 33.2%
- Triglyceride glucose (TyG)
- 36.5%
- Triglyceride glucose-body mass index (TyG-BMI)
- - 10.4%
- Triglyceride glucose-waist circumference (TyG-WC)
- 37.4%
- Triglyceride glucose-waist height ratio (TyG-WHtR)
- 48.5%
Prediction of MASLD onset (time-dependent ROC)
- TyG-BMI had superior predictive ability for MASLD onset vs other indicators
Original publication
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