Lipids & metabolic liver disease
Association of atherogenic index of plasma with cardiovascular disease mortality and all-cause mortality in the general US adult population: results from NHANES 2005–2018
Authors' conclusion
A J-shaped relationship was observed between baseline AIP levels and ACM within the general US population, with a threshold of 0.0905. Moreover, AIP could potentially be an effective predictor for future ACM or CVM, particularly among individuals aged 40-60. Further investigation is warranted to corroborate these findings.
Study context
- Population
- US adults aged ≥ 18, National Health and Nutrition Examination Survey (2005–2018)
- Participants
- 18,133 adults
- Exposure
- Baseline atherogenic index of plasma (AIP) levels
- Outcome
- CVM and ACM
- Follow-up
- Through December 31, 2019
Methodological detailsNHANES 2005–2018, linkage with National Death Index, multivariable Cox proportional hazard models, restricted cubic splines, subgroup analyses
- NHANES 2005–2018
- Linkage with National Death Index
- Multivariable Cox proportional hazard models
- Restricted cubic splines
- Subgroup analyses
Main finding
As reported in the abstract
HR for all-cause mortality (ACM) when baseline AIP exceeded 0.0905
1.61
95% CI 1.08–2.37
All-cause deaths
1870
CVD-related deaths
579
HR for CVM after adjusting for confounders (not statistically significant)
1.31
95% CI 0.93–1.86
Observational data: associations, not effects.
Further findings
ACM and CVM, 40-60-year age group
- HR for ACM, age 40-60
- 1.51 (1.08v2.10)
- HR for CVM, age 40-60
- 2.63 (1.39-4.98)
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →