Lipids & metabolic liver disease
Fasting Plasma Glucose Mediates the Association Between the Atherogenic Index of Plasma and Depression in US Adults: A Study From NHANES 2005-2020
Main finding · Odds of depressionResult — go to the resultOdds ratio 1.44 95% CI 1.03–2.02Authors' conclusion
AIP is positively associated with depression, with FPG statistically explaining a significant portion of this association.
Study context
- Population
- US adults, National Health and Nutrition Examination Survey (2005–2020); depression defined by Patient Health Questionnaire-9
- Participants
- 10,080 adults
- Exposure
- Highest vs lowest atherogenic index of plasma quartile
- Outcome
- Depression (Patient Health Questionnaire-9)
Methodological detailsNHANES 2005-2020, multivariable logistic regression, restricted cubic splines, subgroup and interaction analyses, mediation analysis
- NHANES 2005-2020
- Multivariable logistic regression
- Restricted cubic splines
- Subgroup and interaction analyses
- Mediation analysis
Main finding
Odds of depression
Odds ratio
1.44
95% CI 1.03–2.02
Q4vs Q1
OR 1.44 (95% CI 1.03–2.02)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mediation by fasting plasma glucose (FPG) of the atherogenic index of plasma (AIP)–depression association
- Proportion of total association accounted for by FPG
- 10.42%
Original publication
Fasting Plasma Glucose Mediates the Association Between the Atherogenic Index of Plasma and Depression in US Adults: A Study From NHANES 2005-2020. Endocr Pract. Published 17 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →