Lipids & metabolic liver disease
Association between triglyceride glucose-waist height ratio index and cardiovascular disease in middle-aged and older Chinese individuals: a nationwide cohort study
Authors' conclusion
For middle-aged and older adults, changes in the TyG-WHtR are independently associated with the risk of CVD. Maintaining a favorable TyG index, effective weight management, and a reasonable waist circumference contribute to preventing CVD.
Study context
- Population
- Middle-aged and older Chinese adults, China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 3,312 participants
- Exposure
- Triglyceride glucose-waist height ratio (TyG-WHtR) change groups vs consistently low and stable TyG-WHtR
- Outcome
- CVD (self-reported heart disease and stroke)
- Follow-up
- 2015–2020
Methodological detailsnationwide, K-means cluster analysis, multivariable binary logistic regression, restricted cubic spline regression
- Nationwide
- K-means cluster analysis
- Multivariable binary logistic regression
- Restricted cubic spline regression
Main finding
As reported in the abstract
CVD · 2015–2020
Each group vs low and stableOdds ratio (95% CI)
Moderate and increasing
1.28(1.01–1.63)
High, slowly increasing
1.58(1.16–2.15)
- Participants who developed cardiovascular diseases (CVD)
- 623 (18.8%)
Observational data: associations, not effects.
Further findings
Cumulative TyG-WHtR and CVD events (per SD)
- Higher cumulative TyG-WHtR independently associated with higher CVD risk, per SD OR
- 1.27 (1.12-1.43) (95% CI)
Original publication
Association between triglyceride glucose-waist height ratio index and cardiovascular disease in middle-aged and older Chinese individuals: a nationwide cohort study. Cardiovasc Diabetol. Published 11 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →