Lipids & metabolic liver disease
Associations of cumulative exposure and dynamic trajectories of cholesterol-HDL-glucose (CHG) index with cardiovascular disease in middle-aged and older Chinese adults: a longitudinal analysis
Authors' conclusion
Our research indicates that both cuCHG and CHG changes are associated with CVD risk in middle-aged and older adults, particularly for those with consistently high-risk CHG levels, which are linked to a significantly increased CVD risk. In clinical practice, monitoring long-term CHG changes and maintaining relatively stable levels may help prevent CVD in this population.
Study context
- Population
- Adults aged ≥45 years, China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 6,171 adults
- Exposure
- Cumulative CHG quartiles and CHG trajectories
- Outcome
- Incident CVD (self-reported)
Methodological detailslongitudinal analysis, K-means clustering, Cox proportional hazards regression, restricted cubic spline
- Longitudinal analysis
- K-means clustering
- Cox proportional hazards regression
- Restricted cubic spline
Main finding
As reported in the abstract
Incident CVD
Hazard ratio (95% CI)P value
Cluster 2vs Cluster 3
1.28(1.10–1.49)
P = 0.002Cluster 1vs Cluster 3
1.09(0.98–1.21)
P = 0.126Q4vs Q1
1.22(1.06–1.40)
P = 0.005, adjusted P = 0.007- Incident CVD, overall
- 1,136 (18.4%)
- CVD risk increased across ascending cuCHG quartiles
- P for trend < 0.05
- Linear association between cuCHG and CVD risk (RCS)
- for overall, P < 0.001
Observational data: associations, not effects.
Original publication
Associations of cumulative exposure and dynamic trajectories of cholesterol-HDL-glucose (CHG) index with cardiovascular disease in middle-aged and older Chinese adults: a longitudinal analysis. Cardiovasc Diabetol. Published 15 March 2026. doi:10.
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