Lipids & metabolic liver disease
Association of cumulative cholesterol-HDL-glucose index with blood pressure changes and risk of new-onset hypertension in middle-aged and older adults: a cohort study
Authors' conclusion
Our findings indicate that an elevated cumulative CHG index serves as an independent risk factor for incident hypertension in middle-aged and elderly populations. Although CHG levels exhibited a population-wide decline during the follow-up period, baseline levels were more effective in identifying individuals at long-term high risk.
Study context
- Population
- Middle-aged and older adults, China Health and Retirement Longitudinal Study (CHARLS); baseline 2011, follow-up 2015
- Exposure
- High vs low-stable cumulative CHG index
- Outcome
- Incident hypertension and blood pressure changes
- Follow-up
- 2011 to 2015
Methodological detailslongitudinal, K-means clustering, multivariable logistic and linear regression
- Longitudinal
- K-means clustering
- Multivariable logistic and linear regression
Main finding
As reported in the abstract
4-year follow-up
Odds ratio (incident hypertension) (95% CI)
Group 2vs Group 1
1.61(1.26–2.07)
- Group 2 vs Group 1
- β (systolic BP) 3.89 (95% CI 2.23–5.55)
- Group 2 vs Group 1
- β (diastolic BP) 0.93 (95% CI 0.35–1.50)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Cumulative CHG quartiles, Q4 vs Q1Q4vs Q1 | difference in systolic BP 4.83 mmHg (95% CI 2.58–7.08) | |
| Cumulative CHG quartiles, Q4 vs Q1Q4vs Q1 | difference in diastolic BP 1.52 mmHg (95% CI 0.12–2.93) | |
| −50510Difference, mmHg (linear scale) |
| Outcome | Fold increased risk of incident hypertension (95% CI) |
|---|---|
| Cumulative CHG quartiles, Q4 vs Q1Q4 vs Q1 | 1.72 (1.21–2.43) |
Dose-response
- Linear association between cumulative CHG and outcomes (spline)
Predictive performance (ROC)
- Cumulative CHG comparable to cumulative AIP for predicting incident hypertension
Subgroups
- Interactions between cumulative CHG and cardiovascular diseases (CVD) or CKD
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of cumulative cholesterol-HDL-glucose index with blood pressure changes and risk of new-onset hypertension in middle-aged and older adults: a cohort study. Cardiovasc Diabetol. Published 20 January 2026. doi:10.
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