Lipids & metabolic liver disease
Prognostic effect of triglyceride glucose-related parameters on all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: evidence from international multi-cohort studies
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.55 95% CI 1.10–2.18Authors' conclusion
Higher TyG-ABSI is associated with an increased risk of advanced CKM syndrome and mortality. It further emphasizes the role of TyG-ABSI in the management of CKM syndrome stages and the risk of all-cause mortality and cardiovascular mortality.
Study context
- Population
- Participants with CKM syndrome from China Health and Retirement Longitudinal Study (CHARLS) (China); validation in National Health and Nutrition Examination Survey (NHANES)CHARLS
- Participants
- 11,235 participants
- Exposure
- TyG-a body shape index (TyG-ABSI) tertiles and continuous TyG-ABSI
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Median 5 years
Methodological detailsmulti-cohort, multivariate Cox regression, NHANES validation cohort
- Multi-cohort
- Multivariate Cox regression
- NHANES validation cohort
Main finding
All-cause mortality
Hazard ratio
1.55
95% CI 1.10–2.18
T3vs T1
HR 1.55 (95% CI 1.10–2.18)
As reported in the abstract
- TyG-ABSI (continuous) and all-cause mortality, HR
- 1.14 (95% CI 1.04-1.35)
- All-cause deaths
- 747 (6.65%)
- CV deaths
- 84 (0.75)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Advanced CKM syndrome | 2.41 (1.18–3.20) | |
| 0.20.5125Odds ratio (log scale) |
- Advanced CKM syndrome — TyG-ABSI and CKM syndrome, OR
- 1.55 (95% CI 1.35-1.79)
Mediation of TyG-ABSI–all-cause mortality association
- Proportion mediated by white blood cell (WBC)
- 15.16%
- Proportion mediated by C-reactive protein (CRP)
- 11.83%
- Partial mediation
NHANES validation: all-cause and CV mortality · 10 years follow-up
- Significant positive association of TyG-ABSI with all-cause and CV mortality in CKM syndrome (15,054 participants)
Original publication
Prognostic effect of triglyceride glucose-related parameters on all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: evidence from international multi-cohort studies. Cardiovasc Diabetol. Published 19 January 2026. doi:10.
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