Lipids & metabolic liver disease
Association of cholesterol, high-density lipoprotein and glucose (CHG) index with mortality risk in metabolic dysfunction-associated steatotic liver disease (MASLD) adults: results from two prospective cohorts
Authors' conclusion
Our study confirmed a robust association between the CHG index and ACM and CVM in patients with MASLD based on the two prospective cohorts of NHANES and HRS.
Study context
- Population
- Adults with MASLD, National Health and Nutrition Examination Survey (NHANES) 1999–2018; external validation in Health and Retirement Study (HRS) 2016 cohort2,914 HRS validation
- Participants
- 13,286 adults
- Exposure
- CHG index vs mortality risk
- Outcome
- All-cause mortality (ACM) and cardiovascular mortality (CVM)
- Follow-up
- Median 112 months
Methodological detailstwo prospective cohorts, external validation
- Two prospective cohorts
- External validation
Main finding
As reported in the abstract
median 112 months
ACM cases
1,688
Cardiovascular mortality (CVM) cases
551
Observational data: associations, not effects.
Further findings
Subgroups
- Association more significant in subgroups <60 years and lean
Mediation
- WWI, neutrophil (NE) and estimated glucose disposal rate (eGDR) may partially mediate effects of CHG index on ACM and CVM
External validation (HRS)
- CHG index significantly correlated with ACM
Original publication
Association of cholesterol, high-density lipoprotein and glucose (CHG) index with mortality risk in metabolic dysfunction-associated steatotic liver disease (MASLD) adults: results from two prospective cohorts. Cardiovasc Diabetol. Published 17 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →