Lipids & metabolic liver disease
Relationship between nine triglyceride-glucose-related indices and cardiometabolic multimorbidity incidence in patients with cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study
Authors' conclusion
Nine TyG-related indices, particularly TyG-CVAI, are strong independent predictors of future CMM in patients with CKM syndrome stage 0-3. These findings underscore the utility of TyG-related indices, particularly TyG-CVAI, in identifying high-risk individuals, thereby informing strategies for the early detection and prevention of CKM syndrome.
Study context
- Population
- Participants with cardiovascular-kidney-metabolic (CKM) syndrome stage 0–3, China Health and Retirement Longitudinal Study (CHARLS), 2011–2020
- Exposure
- Highest vs lowest quartiles of nine triglyceride-glucose (TyG)-related indices
- Outcome
- Incident cardiometabolic multimorbidity (CMM)
- Follow-up
- Median 9 years
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Participants who developed cardiometabolic multimorbidity (CMM)
652
9.5%
Elevated CMM risk across highest quartiles of all indices (fully adjusted model); hazard increases
72 to over 200%
Observational data: associations, not effects.
Further findings
Predictive performance for CMM
- Highest AUC for CMM prediction: Triglyceride glucose-Chinese visceral adiposity index (TyG-CVAI)
- 0.679
- All indices provided significant incremental predictive value vs fully adjusted model (Model 4)
Original publication
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