Lipids & metabolic liver disease
Association of the triglyceride glucose-Chinese visceral adiposity index with incident cardiometabolic multimorbidity in middle-aged and older adults: a nationwide prospective cohort study
Authors' conclusion
Both the baseline and cumulative TyG-CVAI are independent and nonlinear predictors of incident CMM, outperforming TyG or CVAI alone. This easily obtainable metric may enhance risk stratification and help identify high-risk individuals for early preventive intervention.
Study context
- Population
- Middle-aged and older adults, China Health and Retirement Longitudinal Study (CHARLS); Cohort 1 baseline TyG-CVAI, Cohort 2 cumulative TyG-CVAItwo cohorts · Cohort 1 8,895 · Cohort 2 5,839
- Exposure
- Highest vs lowest quartile of baseline and cumulative TyG-CVAI
- Outcome
- Incident cardiometabolic multimorbidity (CMM), confirmed via self-reported physician diagnosis, medication use and clinical data
Methodological detailsnationwide, two cohorts from CHARLS
- Nationwide
- Two cohorts from CHARLS
Main finding
As reported in the abstract
Incident CMM
Highest quartile vs Lowest quartileHazard ratio (95% CI)
Baseline TyG-CVAI (Cohort 1)
1.93(1.46–2.54)
Cumulative TyG-CVAI (Cohort 2)
1.76(1.22–2.53)
- Incident cardiometabolic multimorbidity (CMM) cases, Cohort 1
- 875
- Incident CMM cases, Cohort 2
- 492
Observational data: associations, not effects.
Further findings
Nonlinearity (restricted cubic splines)
- Significant nonlinear relationships with threshold effects for both indices
- P for nonlinearity < 0.001
Predictive performance (ROC analysis)
- Baseline and cumulative TyG-CVAI had larger AUC for CMM than TyG or CVAI alone
Original publication
Association of the triglyceride glucose-Chinese visceral adiposity index with incident cardiometabolic multimorbidity in middle-aged and older adults: a nationwide prospective cohort study. Cardiovasc Diabetol. Published 4 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →