Lipids & metabolic liver disease
Characteristics of Dyslipidemia in Adults With Resistance to Thyroid Hormone β
Authors' conclusion
The dyslipidemia associated with RTHβ shares recognized contributory factors found in studies of the general population but appears independent of thyroid status. The reason for the significant inverse association between circulating reverse triiodothyronine and serum triglyceride concentrations is unclear and merits further investigation.
Study context
- Population
- Genetically-confirmed individuals with RTHβ; mean age 40.0 years, 40% malesgenetically-confirmed RTHβ
- Participants
- 105 individuals
- Outcome
- Determinants of dyslipidemia (raised serum LDL-C and TG, reduced HDL-C)
Methodological detailsmultivariable linear regression
- Multivariable linear regression
Main finding
As reported in the abstract
Determinants of dyslipidemia
- Age positively related to serum total and LDL-C
- P < .001
- Similar directional associations: BMI with total:HDL-C ratio, and HOMA-IR with serum TG
- P ≤ .007
- Only thyroid function measure: inverse association between reverse triiodothyronine and serum TG
- P = .009
Observational data: associations, not effects.
Original publication
Characteristics of Dyslipidemia in Adults With Resistance to Thyroid Hormone β. Endocr Pract. Published 5 July 2025. doi:10.
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