Lipids & metabolic liver disease
Lipoprotein(a) and carotid intima-media thickness in children with familial hypercholesterolaemia in the Netherlands: a 20-year follow-up study
Authors' conclusion
Our findings suggest that lipoprotein(a) concentrations contribute significantly to arterial wall thickening in children with familial hypercholesterolaemia who were followed-up until adulthood, suggesting that lipoprotein(a) is an independent and additional risk factor for early atherosclerosis in those already at increased risk. Lipoprotein(a) measurement in young patients with familial hypercholesterolaemia is crucial to identify those at potentially highest risk for cardiovascular disease.
Study context
- Population
- Children aged 8–18 years with heterozygous familial hypercholesterolaemia, randomised in a statin trial in Amsterdam (Netherlands), 1997–1999, followed into adulthood; mean age 13.0 years, 53% male200 analysed
- Participants
- 214 children
- Outcome
- Association between lipoprotein(a) and carotid intima-media thickness progression
- Follow-up
- Baseline, 2, 10 and 20 years
Methodological details20-year follow-up of children randomised in a statin trial, linear mixed-effects models, adjusted for sex, age, corrected LDL-C, statin use and BMI
- 20-year follow-up of children randomised in a statin trial
- Linear mixed-effects models
- Adjusted for sex, age, corrected LDL-C, statin use and BMI
Main finding
As reported in the abstract
Adjusted β, mm per 50 nmol/L lipoprotein(a) increase
0.0073
95% CI 0.0013–0.0132p=0.017
Observational data: associations, not effects.
Further findings
Baseline lipoprotein(a) and carotid intima-media thickness
- Median lipoprotein(a), nmol/L (IQR 8.7-35.5)
- 18.5
- Mean carotid intima-media thickness, mm (SD 0.0496)
- 0.4465
Original publication
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