Lipids & metabolic liver disease
Triglyceride-glucose index: carotid intima-media thickness and cardiovascular risk in a European population
Authors' conclusion
TyG index is a sensitive marker of risk in a European population with moderate ASCVD risk, as assessed by c-IMT measurements, in a large cohort of Lipid Clinic patients.
Study context
- Population
- Primary prevention patients with carotid intima media thickness (c-IMT) measurement 1984–2018, Dyslipidemia Center, Niguarda, Milan, Italy; mean age 54.9 ± 13.1 years, mean BMI 24.6 ± 3.5 Kg/m²
- Participants
- 3,108 patients
- Exposure
- Triglyceride-glucose (TyG) index quartiles
- Outcome
- Association of TyG index with c-IMT
Methodological detailssingle-centre, Lipid Clinic cohort, follow-up up to 20 years
- Single-centre
- Lipid Clinic cohort
- Follow-up up to 20 years
Main finding
As reported in the abstract
- Significant association between the TyG index and all c-IMT measurements
- Significantly higher IMTmean and IMTmax in highest vs lower TyG quartiles; consistent across all vascular sites and significant after adjustment for all potential confounders
Observational data: associations, not effects.
Further findings
Atherosclerotic cardiovascular diseases (ASCVD) events · follow-up up to 20 years
- Kaplan-Meier analysis: increased incidence of ASCVD events in the two highest TyG index quartiles
Mean TyG index
- Mean TyG index
- 8.65 ± 0.59
Original publication
Triglyceride-glucose index: carotid intima-media thickness and cardiovascular risk in a European population. Cardiovasc Diabetol. Published 13 January 2025. doi:10.
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