Lipids & metabolic liver disease
Association between triglyceride-glucose (TyG) related indices and cardiovascular diseases and mortality among individuals with metabolic dysfunction-associated steatotic liver disease: a cohort study of UK Biobank
Authors' conclusion
TyG-related indices, especially TyG-WC and TyG-WHtR, had significant predictive values for the risk of incident CVD and mortality in individuals with MASLD. TyG-related indices may serve as effective surrogate predictors of CVD and mortality in MASLD patients.
Study context
- Population
- MASLD patients free of cardiovascular disease (CVD) at baseline, UK Biobank; median age 58.0 years
- Participants
- 97,331 patients
- Exposure
- Fourth vs first quartile of TyG-related indices
- Outcome
- Overall CVD, CHD, stroke, all-cause mortality and cardiovascular mortality
- Follow-up
- Median 13.56 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
Overall CVD
Estimate (95% CI)
Q4vs Q1
HR (TyG) 1.19(1.13–1.25)
Q4vs Q1
HR (TyG-BMI) 1.35(1.28–1.42)
Q4vs Q1
HR (TyG-WC) 1.33(1.26–1.40)
Q4vs Q1
HR (TyG-WHtR) 1.39(1.32–1.46)
- Incident cases: overall CVD
- 13,256
- Incident cases: Coronary heart disease (CHD)
- 10,980
- Incident cases: stroke
- 2,926
- Incident cases: all-cause mortality
- 8,809
- Incident cases: cardiovascular mortality
- 1,796
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic spline (RCS))
- Nonlinear association of TyG with CVD outcomes (all P for nonlinearity < 0.05)
- Linear trends of TyG-BMI, TyG-WC, TyG-WHtR with CVD outcomes (all P for nonlinearity > 0.05, except TyG-WC with stroke)
Predictive performance (C-index, net reclassification index (NRI), IDI)
- TyG-WC and TyG-WHtR had significantly higher C-index, NRI and IDI for CVD and mortality
Original publication
Association between triglyceride-glucose (TyG) related indices and cardiovascular diseases and mortality among individuals with metabolic dysfunction-associated steatotic liver disease: a cohort study of UK Biobank. Cardiovasc Diabetol. Published 13 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →