Lipids & metabolic liver disease
Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation
Authors' conclusion
In patients with MD and RA, circulating apoCIII levels were positively associated with glycoproteins and negatively with hsCRP, in a TG-independent manner. Our results suggest that apoCIII is associated with the low-grade inflammatory profile represented by glycoproteins, independent of triglyceride levels. Additionally, we observed a negative association with hsCRP, which, while seemingly paradoxical, has been reported in previous studies.
Study context
- Population
- Patients with metabolic disorders, patients with rheumatoid arthritis, and controls
- Participants
- 1,242 patients
- Exposure
- MD vs rheumatoid arthritis (RA) vs Controls
- MDn = 906
- RAn = 192
- Controlsn = 144reference
- Outcome
- Associations of circulating apoCIII with hsCRP and glycosylated proteins (Glyc-A, Glyc-B, Glyc-F)
Methodological detailsApoCIII and high sensitivity C-reactive protein (hsCRP) by immunoturbidimetric assays; glycosylated proteins by 1 H-NMR spectroscopy; correlation and multivariate linear regression
- ApoCIII and hsCRP by immunoturbidimetric assays; glycosylated proteins by 1 H-NMR spectroscopy; correlation and multivariate linear regression
Main finding
As reported in the abstract
Associations of apoCIII with inflammation biomarkers
- ApoCIII significantly and positively associated with Glyc-A, Glyc-B and Glyc-F across all cohorts
- Most associations remained significant in MD after adjusting for triglyceride (TG)
- Negative associations between apoCIII and hsCRP in MD and RA, maintained after including TG
Observational data: associations, not effects.
Original publication
Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation. Cardiovasc Diabetol. Published 8 January 2025. doi:10.
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