Lipids & metabolic liver disease
Prevalence and Predictive Features of CT‐Derived Nonalcoholic Fatty Liver Disease in Metabolically Healthy Mild Autonomous Cortisol Secretion (MACS)
Authors' conclusion
Our findings suggest that MACS is associated with an increased risk of NAFLD, and serum cortisol level after 1 mg DST is an independent predictor of NAFLD in patients with MACS.
Study context
- Population
- Metabolically healthy patients with adrenal incidentaloma (MACS or nonfunctioning adrenal incidentaloma (NFAI)); diabetes, CVD, liver disorders and other diseases that may lead to nonalcoholic fatty liver disease (NAFLD) excludedmatched
- Participants
- 40 vs 60
- Exposure
- MACS vs NFAI
- MACSn = 40
- NFAIn = 60reference
- Outcome
- NAFLD prevalence and predictors, evaluated by unenhanced abdominal CT (mean liver attenuation, HU) and noninvasive fatty liver indices
Methodological detailsmatched for age, gender and BMI
- Matched for age, gender and BMI
Main finding
As reported in the abstract
Mean liver attenuation (HU) on unenhanced CT
- MACS had lower mean liver attenuation values than NFAI
- MACS vs NFAI: P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Visceral adiposity index, hepatic steatosis index and fatty liver indexMACS vs NFAI · higher with MACS | P = 0.009 |
| Visceral adiposity index, hepatic steatosis index and fatty liver indexMACS vs NFAI · higher with MACS | P = 0.002 |
| Visceral adiposity index, hepatic steatosis index and fatty liver indexMACS vs NFAI · higher with MACS | P = 0.023 |
Visceral adiposity index, hepatic steatosis index and fatty liver index
- No significant association between mean liver HU value and these indices
Predictors of mean liver HU value (multivariable linear regression)
- Serum cortisol after 1 mg dexamethasone suppression test (DST) significantly associated with mean liver HU value, independent of other traditional risk factors, in various models
Original publication
Prevalence and Predictive Features of CT‐Derived Nonalcoholic Fatty Liver Disease in Metabolically Healthy MACS. Clin Endocrinol (Oxf). Published 2 January 2025. doi:10.
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