Lipids & metabolic liver disease
Increased Growth Hormone (GH)/IGF-I Axis Activity Relates to Lower Hepatic Lipids and Phosphor Metabolism
Authors' conclusion
GH/IGF-I axis activity impacts hepatic lipid and phosphate metabolism in individuals without disorders in GH secretion. Lower GH axis activity is associated with higher IHL and an unfavorable lipid composition, probably mediated by changes in hepatic energy metabolism.
Study context
- Population
- Otherwise metabolically healthy individuals without disorders of GH secretion; mean age 40.6 ± 15 years, BMI 24.5 ± 3 kg/m², IGF-1 68.0 ± 17% upper limit of normal30 females
- Participants
- 59 individuals
- Exposure
- Non-alcoholic fatty liver disease (NAFLD) vs controls
- NAFLDn = 16
- Outcome
- Relation between GH/IGF-1 axis activity (fasting and during OGTT) and intrahepatic lipid (IHL) content and phosphor metabolism (1H/31P magnetic resonance spectroscopy)
Main finding
As reported in the abstract
Correlation of GH/IGF-1 axis with IHL
Fasting GH vs intrahepatic lipid (IHL), R (P = .02)
−0.31
GH during oral glucose tolerance test (OGTT) vs IHL, R (P < .01)
−0.51
IGF-1 vs IHL, R (P = .03)
−0.28
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| GH levels during OGTTSignificantly lower in NAFLD | P = 0.003 |
Lipid composition and phosphor metabolites
- GH/IGF-1 axis activity correlated with lipid composition and with phosphor metabolites
Multiple regression
- GH/IGF-1 axis activity a strong predictor for IHL and lipid composition independent from insulin sensitivity
Original publication
Increased GH/IGF-I Axis Activity Relates to Lower Hepatic Lipids and Phosphor Metabolism. J Clin Endocrinol Metab. Published 27 April 2023. doi:10.
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