Lipids & metabolic liver disease
Rising nonalcoholic fatty liver disease (NAFLD) and metabolic severity during the Sars‐CoV‐2 pandemic among children with obesity in the United States
Authors' conclusion
Hepatic health differences were likely exacerbated by environmental and behavioral changes associated with the pandemic, which are critically important for clinicians to consider when engaging in patient care to help minimize the future risk for metabolic perturbations.
Study context
- Population
- Youth with obesity, Yale Pediatric Obesity Clinic
- Exposure
- Youth with obesity during vs before the Sars-CoV-2 pandemic
- Outcome
- NAFLD prevalence (MRI PDFF ≥ 5.5%)
Methodological detailsfrequency-matched control group, single-centre
- Frequency-matched control group
- Single-centre
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Proton density fat fraction (PDFF) in participants with NAFLD
- Higher PDFF values during vs before the pandemic
Visceral adipose tissue and insulin secretion during OGTT
- Increase in visceral adipose tissue and hyperresponsiveness in insulin secretion during the OGTT
Original publication
Rising NAFLD and metabolic severity during the Sars‐CoV‐2 pandemic among children with obesity in the United States. Obesity (Silver Spring). Published 26 April 2023. doi:10.
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