Lipids & metabolic liver disease
Beta-cell, but not autonomic nervous system, function is related to metabolic-associated fatty liver disease (MAFLD) in early stages of glucose intolerance
Authors' conclusion
Our results do not support a role for parasympathetic activity in MAFLD. Rather, they show that stimulated hyperinsulinemia may be associated with greater risk of MAFLD irrespective of glucose tolerance in a high-risk population without diabetes.
Study context
- Population
- Adults with NGT or IGT without diabetes; Oral glucose tolerance test (OGTT) and mixed meal tolerance test (MMTT), bioimpedance, autonomic function (ANX V.3.0), controlled attenuated parameter (CAP) by Fibroscan; MAFLD defined as CAP >233 dB/m
- Participants
- 25 vs 27
- Exposure
- NGT vs IGT; MAFLD vs no MAFLD
- NGTn = 25reference
- IGTn = 27
- Outcome
- Association of CAP with insulin secretion and action, and with sympathetic and parasympathetic activity
Main finding
As reported in the abstract
Prevalence of CAP >233 dB/m (MAFLD)
- AUC-insulin MMTT independently related to MAFLD (regression), OR
- 24.4 (95% CI 2.17 to 274.77; p=0.010)
Observational data: associations, not effects.
Further findings
Matrix analysis adjusted for age and body mass index (BMI)
- CAP positively related to systolic blood pressure (SBP)
- Insulin action negatively related to parasympathetic activity
AUC-insulin MMTT cut-off for CAP >233 dB/m
- Cut-off 15,620 uIU/mL-1*180 min-1: sensitivity
- 75%
- Cut-off 15,620 uIU/mL-1*180 min-1: specificity
- 75%
Original publication
Beta-cell, but not autonomic nervous system, function is related to MAFLD in early stages of glucose intolerance. BMJ Open Diabetes Res Care. Published 20 December 2024. doi:10.
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