Lipids & metabolic liver disease
Acute Statin Withdrawal Does not Interfere With the Improvements of a Session of Exercise in Postprandial Metabolism
Authors' conclusion
In dyslipidemic individuals, statins reduce blood triglyceride concentrations after a meal, but without limiting fat oxidation. Statins do not interfere with exercise lowering the postprandial insulin that likely promotes fat oxidation. Last, statins do not restrict the rates of plasma incorporation or oxidation of the ingested glucose.
Study context
- Population
- Individuals with dyslipidemia and metabolic syndrome treated with statins, undergoing a mixed-meal (970 ± 111 kcal, 24% fat, 34% carbohydrate) tolerance testcrossover
- Participants
- 11 individuals
- Comparison
- Habitual statin treatment vs 96 h statin withdrawal, each with and without a prior session of low-intensity exercise
Methodological detailsrandomized crossover, blinded statin withdrawal
- Randomized crossover
- Blinded statin withdrawal
Primary result
Postprandial plasma TG
Reduction
17%
P = 0.015
By group
As reported in the abstract
Further findings
| Outcome | Exercise | No exercise | P value |
|---|---|---|---|
| Postprandial plasma insulinExercise vs No exercise | 241 ± 116 ρmol·L-1 | 301 ± 172 ρmol·L-1 | P = 0.026 |
- Postprandial plasma glycerol with prior exercise · Exercise vs No exercise · increased with Exercise
- P = 0.029
- Postprandial fat oxidation rates with prior exercise · Exercise vs No exercise · increased with Exercise
- P = 0.024
- Insulin sensitivity with exercise · Exercise vs No exercise · not increased
- P = 0.614
Postprandial plasma glycerol, free fatty acids and fat oxidation with statins
- Statins reduced plasma glycerol (surrogate of whole-body lipolysis) without reducing plasma free fatty acid concentration or fat oxidation
Plasma glucose appearance rates (exogenous and endogenous)
- Neither statins nor exercise affected plasma glucose appearance rates from exogenous or endogenous sources
Original publication
Acute Statin Withdrawal Does not Interfere With the Improvements of a Session of Exercise in Postprandial Metabolism. J Clin Endocrinol Metab. Published 11 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →