Lipids & metabolic liver disease
Associations of Sugar-Sweetened Beverages, Artificially Sweetened Beverages, and Pure Fruit Juice With Nonalcoholic Fatty Liver Disease: Cross-sectional and Longitudinal Study
Authors' conclusion
Consumption of SSB, ASB, and PJ were all related to the risk of NAFLD. Excessive consumption of ASBs was associated with an increased risk of incident hospitalized NAFLD.
Study context
- Population
- UK Biobank participants who completed the dietary questionnaire, without history of liver disease
- Participants
- 136,277 participants
- Exposure
- Sugar-sweetened beverages (SSB), artificially sweetened beverages (ASB) and PJ consumption vs 0 L/wk
- Outcome
- NAFLD defined by fatty liver index ≥60 (cross-sectional); hospitalized NAFLD (ICD-10 K76.0, K75.8) (longitudinal)
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
NAFLD (FLI ≥60), cross-sectional
Each group vs 0 L/wkAdjusted odds ratio (95% CI)
≤1 L/wkSSB
1.06(1.02–1.10)
1 to 2 L/wkSSB
1.24(1.19–1.29)
>2 L/wkSSB
1.42(1.35–1.49)
≤1 L/wkASB
1.43(1.37–1.50)
1 to 2 L/wkASB
1.73(1.65–1.82)
>2 L/wkASB
2.37(2.25–2.50)
≤1 L/wkPJ
0.87(0.84–0.89)
1 to 2 L/wkPJ
0.91(0.88–0.94)
>2 L/wkPJ
1.07(1.02–1.13)
Observational data: associations, not effects.
Further findings
| Outcome | Increased risk (CI) | P value |
|---|---|---|
| Hospitalized NAFLD (longitudinal), ASB · median follow-up 10.2 years1 to 2 L/wk vs 0 L/wk · ASB | 22% (0.99–1.50) | |
| Hospitalized NAFLD (longitudinal), ASB · median follow-up 10.2 years>2 L/wk vs 0 L/wk · ASB | 35% (1.11–1.65) | P for trend = 0.002 |
- Hospitalized nonalcoholic fatty liver disease (NAFLD) (longitudinal), ASB — Hospitalized NAFLD cases
- 1043
Fatty liver index (FLI)
- SSB and ASB consumption both positively correlated with FLI
- P for line < .001
Hospitalized NAFLD (longitudinal), ASB · median follow-up 10.2 years
- Associations of SSB and PJ with hospitalized NAFLD not significant
Original publication
Associations of Sugar-Sweetened Beverages, Artificially Sweetened Beverages, and Pure Fruit Juice With Nonalcoholic Fatty Liver Disease: Cross-sectional and Longitudinal Study. Endocr Pract. Published 3 August 2023. doi:10.
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