Lipids & metabolic liver disease
Impact of peripheral thyroid hormone balance on liver fat: insights from the NutriAct trial
Authors' conclusion
Altered TH balance indicates a possible compensatory upregulation of whole-body TH activity in subjects with increased liver fat. This might be also relevant during the improvement of hepatic steatosis.
Study context
- Population
- Subjects aged 50–80 years with ≥1 risk factor for unhealthy aging; euthyroid subgroup without significant alcohol consumption332 euthyroid subgroup
- Participants
- 502 subjects
- Comparison
- Diet rich in unsaturated fatty acids, plant protein and fiber vs German Nutrition Society recommendations
Methodological details36-month
- 36-month
Primary result
As reported in the abstract
Association of thyroid function with IHL · baseline to 12 months
- Only fT3 and T3/T4 ratios showed a significant positive correlation with IHL at baseline
- Significant decline in fT3, T3, fT3/fT4 ratio and T3/T4 ratio in CG and IG after 12 months, without significant differences between groups
- TSH, fT4 and T4 remained stable
- Larger improvement of IHL during dietary intervention in subjects with a lower decline in T3
- 243 measured at 12 months
Original publication
Impact of peripheral thyroid hormone balance on liver fat: insights from the NutriAct trial. Eur J Endocrinol. Published 25 July 2024. doi:10.
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