Lipids & metabolic liver disease
Glucose metabolism and radiodensity of abdominal adipose tissue: A 5‐year longitudinal study in a large PET cohort
Authors' conclusion
Ageing led to increased glucose metabolism and radiodensity in VAT, but not in SAT. VAT may reflect the ageing process more directly than SAT. Glucose metabolism was higher and radiodensity was lower in VAT than in SAT, probably owing to differences in gene expression and lipid density. Both glucose metabolism and radiodensity of VAT and SAT reflect metabolic status.
Study context
- Population
- Healthy men (mean 42.8 years) undergoing a health check-up programme twice, at baseline and 5-year follow-up, with 18F-FDG PET/CT
- Participants
- 435 men
- Outcome
- Change in SUVR and HU of VAT and SAT
- Follow-up
- 5-year follow-up
Methodological details5-year follow-up, Bayesian hierarchical modelling
- 5-year follow-up
- Bayesian hierarchical modelling
Main finding
As reported in the abstract
- SUVR and Hounsfield units (HU) of visceral adipose tissue (VAT) increased during follow-up
- SUVR and HU of subcutaneous adipose tissue (SAT) did not change
- All clinical variables changed during follow-up
Observational data: associations, not effects.
Further findings
Associations of SUVR and HU
- SUVR and HU positively correlated in both VAT and SAT
- SAT and VAT SUVR negatively associated with metabolic clusters
Original publication
Glucose metabolism and radiodensity of abdominal adipose tissue: A 5‐year longitudinal study in a large PET cohort. Clin Endocrinol (Oxf). Published 22 July 2024. doi:10.
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