Lipids & metabolic liver disease
Hepatic steatosis is associated with impaired hepatic glucose uptake under hyperglycemic conditions, a dynamic whole-body 18F-FDG PET approach
Authors' conclusion
We show that another aspect of hepatic insulin resistance, namely the ability of insulin to stimulate hepatic glucose uptake under hyperglycemic conditions, is negatively associated with hepatic fat content. This suggests that hepatic glucose uptake is another factor that may be important in Metabolic dysfunction Associated Steatotic Liver Disease (MASLD) and the risk for type 2 diabetes, and needs further investigation.
Study context
- Population
- Participants with a range of liver fat content (0.9–18 %) assessed by 1H-MRS
- Participants
- 15 participants
- Outcome
- Hepatic glucose uptake under hyperglycemia and hyperinsulinemia in relation to hepatic steatosis
Methodological detailsdynamic whole-body 18F-FDG PET, two-step euglycemic-hyperinsulinemic clamp, hyperglycemic-hyperinsulinemic clamp
- Dynamic whole-body 18F-FDG PET
- Two-step euglycemic-hyperinsulinemic clamp
- Hyperglycemic-hyperinsulinemic clamp
Main finding
As reported in the abstract
Strong inverse correlation of hepatic glucose uptake with liver fat content
r = −0.756
p < 0.001
Observational data: associations, not effects.
Further findings
Hepatic glucose uptake vs insulin-stimulated endogenous glucose production (EGP) suppression
- Correlation of hepatic glucose uptake with insulin-stimulated EGP suppression
- r = 0.616, p = 0.015
Adipose tissue insulin sensitivity
- Negatively associated with liver fat content and positively with hepatic, skeletal muscle and adipose tissue glucose uptake
Original publication
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