Lipids & metabolic liver disease
Association of chronic kidney disease and type 2 diabetes mellitus with metabolic dysfunction-associated steatotic liver disease and liver fibrosis assessed by transient elastography: a cross-sectional study based on National Health and Nutrition Examination Survey (NHANES) 2017–2020
Authors' conclusion
T2DM with CKD is associated with increased LF risk, while T2DM alone is linked to higher MASLD risk.
Study context
- Population
- American adults in NHANES 2017–March 2020; hepatic steatosis and liver fibrosis diagnosed by transient elastography
- Participants
- 6,035 adults
- Exposure
- Chronic kidney disease (CKD) and/or T2D vs neither
- Outcome
- Prevalence risks of MASLD and liver fibrosis (LF)
Methodological detailsNHANES 2017–March 2020, logistic regression
- NHANES 2017–March 2020
- Logistic regression
Main finding
As reported in the abstract
LF, comorbid cases excluded
Each group vs without CKD or T2DMOdds ratio (CI)
T2DM + CKD
3.495(2.671–4.574)
T2DM-only
1.662(1.126–2.451)
CKD-only
1.384(1.068–1.794)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Comorbidities not excludedCKDvs non-CKD | OR for MASLD 1.266 (CI 1.024–1.566) | |
| Comorbidities not excludedCKDvs non-CKD | OR for LF 1.817 (CI 1.518–2.174) | |
| Comorbidities not excludedT2DMvs non-T2DM | OR for MASLD 2.418 (CI 1.937–3.017) | |
| Comorbidities not excludedT2DMvs non-T2DM | OR for LF 2.163 (CI 1.658–2.821) | |
| 0.20.5125Ratio (log scale) |
Prevalence of MASLD and liver fibrosis (LF)
%
- MASLD prevalence
- 27
- LF prevalence
- 16
Subgroup analyses
- Elevated risks across all strata for combined T2DM + CKD
Original publication
Association of chronic kidney disease and type 2 diabetes mellitus with metabolic dysfunction-associated steatotic liver disease and liver fibrosis assessed by transient elastography: a cross-sectional study based on NHANES 2017–2020. Diabetes Res Clin Pract. Published 11 August 2025. doi:10.
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