Comparison of Risk Factors Between Lean and Nonlean Metabolic Dysfunction-Associated Steatotic Liver Disease in Individuals With Type 2 Diabetes: A Multicenter Study
Authors' conclusion
In lean patients with T2DM, liver steatosis and fibrosis were less associated with insulin resistance. Risk factors of liver steatosis were different between lean and nonlean patients, indicating the necessity of risk stratification and tailored management strategies.
Study context
- Population
- Patients with T2D from 16 centers undergoing transient elastography for liver steatosis and fibrosis
- Participants
- 1,762 patients
- Exposure
- Lean vs nonlean patients with T2D
- Outcome
- Prevalence of liver steatosis and fibrosis in lean patients
Methodological details16 centers
- 16 centers
Main finding
As reported in the abstract
Liver steatosis prevalence, lean
44.7%
Liver fibrosis prevalence, lean
23.4%
Observational data: associations, not effects.
Further findings
Hypertension and CVD
- Prevalence of hypertension and CVD higher in lean vs nonlean patients
Characteristics of lean patients with steatosis or fibrosis
- Older, longer diabetes duration, lower HOMA-IR and serum lipids
Correlates of liver steatosis
- BMI, visceral fat area and TG among most significant correlators in both lean and nonlean; lipid profiles differed between groups
Correlates of fibrosis in lean
- Insulin resistance, BMI and lipid levels not associated with fibrosis in lean
Original publication
Comparison of Risk Factors Between Lean and Nonlean Metabolic Dysfunction-Associated Steatotic Liver Disease in Individuals With Type 2 Diabetes: A Multicenter Study. Endocr Pract. Published 25 September 2024. doi:10.
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