Obesity increases the risk of hepatic fibrosis in young adults with type 2 diabetes mellitus: the need to screen
An erratum to this article was published (Obesity (Silver Spring), Dec 2024 ↗)
Authors' conclusion
There is a high prevalence of clinically significant hepatic fibrosis in young adults with cardiometabolic risk factors. Up to one in seven young adults with obesity and T2D had clinically significant hepatic fibrosis on elastography. This highlights the need to screen young adults with cardiometabolic risk factors for MASLD for early detection and intervention.
Study context
- Population
- Individuals with (63%) and without T2D (37%) attending internal medicine clinics, without known history of MASLD; laboratory evaluation and transient elastography
- Participants
- 1,420 individuals
- Exposure
- Young adults vs older adults
- Young adultsn = 243
- Older adultsn = 1,177reference
- Outcome
- Prevalence of MASLD (hepatic steatosis and fibrosis on transient elastography)
Main finding
As reported in the abstract
Steatosis
Fibrosis
Observational data: associations, not effects.
Further findings
Steatosis and fibrosis in young adults with both obesity and T2D
- Steatosis, significantly higher (p < 0.01)
- 71.1%
- Fibrosis, significantly higher (p < 0.01)
- 15.7%
Risk factors for hepatic fibrosis in young adults
- T2D, OR (95% CI 1.37-13.68); p < 0.05
- 4.33
- Obesity, OR (95% CI 1.07-1.25); p < 0.05
- 1.16
- T2D and obesity were the strongest risk factors
Original publication
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