Lipids & metabolic liver disease
Reduced circulating Mig-6 levels are associated with dysglycemia in metabolic dysfunction associated steatotic liver disease (MASLD)
Authors' conclusion
Serum Mig-6 levels may identify MASLD patients at an increased risk of dysglycemia and positively correlate with pancreatic β-cell dysfunction.
Study context
- Population
- MASLD patients with F2 and F3 fibrosis (FIB-4 1.3–2.67, assessed by vibration-controlled transient elastography); glycaemic status per American Diabetes Association criteriaF2–F3 fibrosis
- Participants
- 119 patients
- Exposure
- Serum Mig-6 in MASLD with normal glucose tolerance (NGT) vs impaired glucose tolerance vs treatment-naïve T2D
- NGTn = 35reference
- Impaired glucose tolerancen = 44
- Treatment-naïve T2Dn = 40
- Outcome
- Serum Mig-6 level in MASLD with or without dysglycemia and its association with HOMA-β
Main finding
As reported in the abstract
Serum Mig-6 level
- Participants with dysglycemia had lower serum Mig-6 levels vs NGT
- p<0.05
- Mig-6 cut-off <97.49 pg/mL predicting dysglycemia in steatohepatitis: sensitivity
- 77.50%
- Mig-6 cut-off <97.49 pg/mL predicting dysglycemia: specificity
- 73.08%
Observational data: associations, not effects.
Further findings
| Outcome | NGT | Treatment-naïve T2D |
|---|---|---|
| Low serum Mig-6 (below cut-off) | 22% | 74.2% |
Metabolic syndrome by FIB-4 (479 MASLD patients)
- Metabolic syndrome with FIB-4>1.3
- 68%
- Metabolic syndrome with FIB-4<1.3
- 27%
- Reduced serum Mig-6 level in FIB-4 >1.3
Mig-6 for identifying β-cell dysfunction
- PPV
- 79.41%
- NPV
- 85.17%
- PPV, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR)>1.6
- 80%
- NPV, HOMA-IR>1.6
- 86.67%
- HOMA-β lower with Mig-6 below cut-off (97.49 pg/mL)
Original publication
Reduced circulating Mig-6 levels are associated with dysglycemia in metabolic dysfunction associated steatotic liver disease (MASLD). BMJ Open Diabetes Res Care. Published 3 June 2026. doi:10.
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