Lipids & metabolic liver disease
Association between C-reactive protein-triglyceride glucose related indices and all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome
Authors' conclusion
Higher CTI-related indices were significantly associated with a higher risk of all-cause and cardiovascular mortality in individuals with CKM syndrome. Among these indices, CTI-ABSI exhibits superior predictive performance, suggesting its potential as practical prognostic biomarkers for CKM patients.
Study context
- Population
- Individuals with cardiovascular-kidney-metabolic (CKM) syndrome, NHANES database
- Participants
- 10,941 individuals
- Exposure
- Higher vs lower CTI-related indices
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Median 12.83 years
Methodological detailsNHANES, Cox regression, restricted cubic spline, ROC analysis, subgroup analyses
- NHANES
- Cox regression
- Restricted cubic spline
- ROC analysis
- Subgroup analyses
Main finding
As reported in the abstract
- Deaths, all-cause
- 20.3% (n = 2223)
- Deaths, cardiovascular
- 6.3% (n = 693)
- All-cause mortality, CTI: HR
- 1.21 (1.14-1.28) (95% CI)
- All-cause mortality, CTI-WHtR: HR
- 1.14 (1.08-1.21) (95% CI)
- All-cause mortality, CTI-WWI: HR
- 1.25 (1.18-1.33) (95% CI)
- All-cause mortality, CTI-ABSI: HR
- 1.29 (1.22-1.37) (95% CI)
- CV mortality, CTI: sHR
- 1.31 (1.18-1.45) (95% CI)
- CV mortality, CTI-WHtR: sHR
- 1.29 (1.16-1.42) (95% CI)
- CV mortality, CTI-WWI: sHR
- 1.39 (1.25-1.55) (95% CI)
- CV mortality, CTI-ABSI: sHR
- 1.40 (1.26-1.55) (95% CI)
Observational data: associations, not effects.
Further findings
Dose-response shape (restricted cubic spline (RCS))
- CTI nonlinearly associated with all-cause and CV mortality; CTI-WWI and CTI-ABSI linear with both; CTI-WHtR nonlinear with all-cause, linear with CV mortality
Predictive ability (ROC)
- CTI-ABSI AUC, all-cause mortality (highest)
- 0.711
- CTI-ABSI AUC, CV mortality (highest)
- 0.690
Subgroups by CKM stage
- Association more pronounced in early CKM stages (0-2) than advanced stages (3-4)
Original publication
Association between C-reactive protein-triglyceride glucose related indices and all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome. Cardiovasc Diabetol. Published 3 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →