Lipids & metabolic liver disease
Adopting the lancet commission definition of clinical obesity in metabolic dysfunction-associated steatotic liver disease (MASLD)
Authors' conclusion
Clinical obesity criteria identified more MASLD patients with F3/F4, severe steatosis, at-risk MASH and MACE compared with BMI-based obesity criteria.
Study context
- Population
- Asian patients with MASLD with vibration-controlled transient elastography assessment; mean age 55.8 ± 12.5 years, 49.2% male, mean BMI 28.2 ± 4.7 kg/m²254 with bioelectrical impedance analysis (BIA)
- Participants
- 642 patients
- Exposure
- Clinical obesity criteria vs BMI-based obesity criteria
- Outcome
- Patients identified with clinical outcomes
Main finding
As reported in the abstract
- Fulfilled the diagnosis of clinical obesity
- 46.1%
- F3/F4: clinical obesity vs BMI-based criteria
- 20.6% vs 8.1%, p < 0.001
- Severe steatosis: clinical obesity vs BMI-based criteria
- 83.8% vs 67.6%, p < 0.001
- At-risk MASH: clinical obesity vs BMI-based criteria
- 3.4% vs 0%, p = 0.056
- Major adverse cardiovascular events (MACE): clinical obesity vs BMI-based criteria
- 11.2% vs 2.7%, p = 0.006
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Clinical obesity as independent predictor of F3/F4 | 4.074 (2.195–7.563) | P < 0.001 | |
| Clinical obesity as independent predictor of severe steatosis | 2.441 (1.638–3.637) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Body composition (BIA subgroup): appendicular skeletal muscle mass and visceral fat index
- Lower appendicular skeletal muscle mass, clinical obesity vs BMI-based criteria
- 27.0% vs 41.1%, P < 0.001
- Greater visceral fat index, clinical obesity vs BMI-based criteria
- 15 vs 9, p < 0.001
Original publication
Adopting the lancet commission definition of clinical obesity in metabolic dysfunction-associated steatotic liver disease (MASLD). Int J Obes (Lond). Published 17 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →