Associations of triglyceride–glucose index cumulative exposure and variability with the transitions from normoglycaemia to prediabetes and prediabetes to diabetes: Insights from a cohort study
Authors' conclusion
Higher cumTyG exposure independently predicts prediabetes and diabetes incidence. Coexisting cumTyG and variability could further yield incrementally greater risks.
Study context
- Population
- Health check-up participants with 3 sequential health examinations during 2012–2016, followed up 2017–2021two subcohorts
- Participants
- 9,373 vs 4,563
- Exposure
- Higher vs lower cumulative triglyceride-glucose (TyG) index and TyG variability
- Normoglycaemia to prediabetes subcohortn = 9,373
- Prediabetes to diabetes subcohortn = 4,563
- Outcome
- Newly incident prediabetes or diabetes
Methodological detailshealth check-up cohort, 3 sequential health examinations 2012-2016, follow-up 2017-2021
- Health check-up cohort
- 3 sequential health examinations 2012-2016, follow-up 2017-2021
Main finding
As reported in the abstract
Prediabetes subcohort: developed prediabetes over a 2.42-year follow-up
2,074
Higher Cumulative TyG (cumTyG) and prediabetes risk, HR
2.02
95% CI 1.70–2.41
Diabetes subcohort: developed diabetes over a 3.0-year follow-up
379
Higher cumTyG and diabetes risk, HR
3.54
95% CI 2.29–5.46
Observational data: associations, not effects.
Further findings
- cumTyG+variability combination had the highest predictive value for prediabetes and diabetes beyond a single baseline TyG measurement
Original publication
Associations of triglyceride–glucose index cumulative exposure and variability with the transitions from normoglycaemia to prediabetes and prediabetes to diabetes: Insights from a cohort study. Diabetes Res Clin Pract. Published 24 September 2024. doi:10.
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