Methylglyoxal Mediates the Association Between 2-Hour Plasma Glucose and HbA1c With Inflammation: The Maastricht Study
Authors' conclusion
MGO mediates the association between postload glucose excursions and HbA1c with inflammation, providing evidence for a role of postprandial MGO formation to hyperglycemia-induced low-grade inflammation.
Study context
- Population
- Participants of The Maastricht Study who underwent an OGTT, with data on methylglyoxal (MGO) levels and inflammation
- Participants
- 3,017 participants
- Outcome
- Low-grade inflammation score (CRP, serum amyloid A, IL-6, IL-8, TNF, sICAM-1) associated with FPG, 2h-PG and HbA1c, and mediation by MGO
Methodological detailspopulation-based phenotyping cohort (The Maastricht Study), linear regression adjusted for potential confounders, mediation analysis
- Population-based phenotyping cohort (The Maastricht Study)
- Linear regression adjusted for potential confounders
- Mediation analysis
Main finding
As reported in the abstract
Association with low-grade inflammation (stdβ, 95% CI)
- 2h-PG with low-grade inflammation, stdβ [95% CI]
- 0.172, [0.110; 0.234]
- HbA1c with low-grade inflammation, stdβ [95% CI]
- 0.148, [0.101; 0.196]
- Fasting plasma glucose (FPG) with low-grade inflammation (not associated), stdβ [95% CI]
- 0.049, [−0.002; 0.100]
- 2h-MGO mediated share of 2h-PG–inflammation association
- 23%
- 2h-MGO mediated share of HbA1c–inflammation association
- 16%
Observational data: associations, not effects.
Further findings
Association with 2h-MGO (stdβ, 95% CI)
- 2h-PG with 2h-MGO
- 0.471, [0.407; 0.534]
- HbA1c with 2h-MGO
- 0.244, [0.195; 0.294]
2h-MGO with low-grade inflammation (independent, positive), stdβ [95% CI]
- 2h-MGO with low-grade inflammation
- 0.078, [0.037; 0.120]
Original publication
Methylglyoxal Mediates the Association Between 2-Hour Plasma Glucose and HbA1c With Inflammation: The Maastricht Study. J Clin Endocrinol Metab. Published 24 September 2024. doi:10.
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