Feasibility of using oral glucose tolerance test (OGTT) 1-h PG as a diagnostic criterion for diabetes and pre-diabetes
Authors' conclusion
The DM prevalence would be significantly higher if the OGTT 1-h PG was adopted as the diagnostic criterion. More prospective studies are needed to validate its clinical utility.
Study context
- Population
- Outpatients who completed a 5-point OGTT
- Participants
- 1,021 outpatients
- Comparison
- OGTT 1-h PG vs OGTT 2-h PG as diagnostic criterion for diabetes mellitus (DM) and pre-diabetes
- Outcome
- Diagnostic value for DM
Performance
As reported in the abstract
| Test or model | AUC |
|---|---|
| OGTT 1-h PG | 93.7% (95% CI 92.2% to 95.1%) |
| OGTT 2-h PG | 96.1% (95% CI 94.7% to 97.3%) |
AUC
OGTT 1-h PG93.7% (95% CI 92.2% to 95.1%)
OGTT 2-h PG96.1% (95% CI 94.7% to 97.3%)
- Agreement for DM when 1-h PG substituted for 2-h PG in American Diabetes Association (ADA) strategy, κ
- 0.7 (95% CI 70.1% to 78.4%)
Further findings
| Outcome | OGTT 1-h PG | OGTT 2-h PG |
|---|---|---|
| Diagnostic value for pre-diabetes | ||
| AUC | 71.8% (95% CI 67.9% to 75.8%) | 70.4% (95% CI 65.9% to 74.5%) |
- Diagnostic value for pre-diabetes — Agreement for pre-diabetes when 1-h PG substituted for 2-h PG in ADA strategy, κ
- 0.7 (95% CI 64.5% to 75.0%)
Prevalence of DM and pre-diabetes by criteria
- ADA standard: DM; pre-diabetes
- 34.1%; 24.4%
- ADA with 2-h PG replaced by 1-h PG: DM; pre-diabetes
- 42.4%; 21.8%
- ADA plus 1-h PG: DM; pre-diabetes
- 44.4%; 20.8%
- WHO criteria: DM; pre-diabetes
- 30.4%; 19.2%
- WHO with 2-h PG replaced by 1-h PG: DM; pre-diabetes
- 40.5%; 21.8%
- WHO plus 1-h PG: DM; pre-diabetes
- 43.9%; 22.2%
Original publication
Feasibility of using OGTT 1-h PG as a diagnostic criterion for diabetes and pre-diabetes. BMJ Open Diabetes Res Care. Published 22 April 2026. doi:10.
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