Simultaneous assessment of one-hour plasma glucose levels and age as a potential predictor of glucose intolerance development in individuals with normal glucose tolerance
Main finding · GI developmentResult — go to the resultSex- and BMI-adjusted OR 12.9 95 % CI 5.7–29.2Authors' conclusion
The combination of 1-h PG and age serves as a potential predictor of GI development in individuals with NGT.
Study context
- Population
- Japanese individuals with normal glucose tolerance (NGT) who completed a 5-year follow-up; 75-g OGTT used to diagnose glucose intolerance (GI)
- Participants
- 1,008 individuals
- Exposure
- 1-h PG ≥ 8.3 mmol/L and age ≥ 57 years vs reference
- Outcome
- GI development (impaired glucose tolerance (IGT) or T2D, and/or impaired fasting glucose)
- Follow-up
- 5 years
Methodological details5-year follow-up
- 5-year follow-up
Main finding
GI development
Sex- and BMI-adjusted OR
12.9
95 % CI 5.7–29.2
1-h PG ≥ 8.3 mmol/L and age ≥ 57 yearsvs Reference
sex- and BMI-adjusted OR 12.9 (95 % CI 5.7–29.2)
As reported in the abstract
Observational data: associations, not effects.
Further findings
T2D susceptibility SNPs (genetic risk)
- Genetic risk was associated with aggravation of 1-h PG levels
Original publication
Simultaneous assessment of one-hour plasma glucose levels and age as a potential predictor of glucose intolerance development in individuals with normal glucose tolerance. Diabetes Res Clin Pract. Published 31 December 2025. doi:10.
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