Differences in target organ damage in individuals with intermediate hyperglycemia and type 2 diabetes identified by 1-hour plasma glucose during an oral glucose tolerance test
Authors' conclusion
The thresholds of 1-hour post-load glucose proposed by IDF as diagnostic criteria for IH and T2D are capable of detecting individuals at risk of cardiovascular target organ damage.
Study context
- Population
- Adults classified by fasting, 1-hour and 2-hour glucose during an oral glucose tolerance test (OGTT) according to the International Diabetes Federation (IDF) recommendation
- Participants
- 1,847 adults
- Exposure
- Intermediate hyperglycemia (IH) and newly diagnosed T2D vs normal glucose tolerance (NGT), classified by fasting, 1-hour and 2-hour OGTT glucose (IDF criteria)
- NGTn = 736reference
- Isolated impaired fasting glucose (iIFG)n = 105
- IHn = 676
- T2Dn = 330
- Outcome
- Cardiovascular target organ damage: LVM index (LVMI) and myocardial mechano-energetic efficiency normalized by LVM (MEEi)
Main finding
As reported in the abstract
LVMI
IH vs NGT: P < 0.001 · T2D vs NGT: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | NGT | IH | T2D | P value |
|---|---|---|---|---|
| MEEiIH vs NGT · decreased with IH | 0.42 ± 0.11 ml/sec*g-1 | 0.37 ± 0.10 ml/sec*g-1 | 0.35 ± 0.11 ml/sec*g-1 | P < 0.001 |
| MEEiT2D vs NGT · decreased with T2D | P < 0.001 |
MEEi
- MEEi did not differ between NGT and iIFG
Original publication
Differences in target organ damage in individuals with intermediate hyperglycemia and type 2 diabetes identified by 1-hour plasma glucose during an oral glucose tolerance test. Diabetes Res Clin Pract. Published 30 November 2024. doi:10.
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